Volume 11, Issue 1 (Vol 11, No 1 2015)                   irje 2015, 11(1): 72-81 | Back to browse issues page

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Panahi M, Yavari P, Khalili D, Mehrabi Y, Hadaegh F, Azizi F. Obesity Paradox: Incidence of Coronary Heart Disease in Patients with Chronic Kidney Disease and Metabolic Syndrome . irje. 2015; 11 (1) :72-81
URL: http://irje.tums.ac.ir/article-1-5351-en.html
1- , p.yavari-grc@sbmu.ac.ir
Abstract:   (8703 Views)

Background & Objectives: Some studies on chronic diseases have indicated that obesity may result in a paradoxically longer survival. The present study was aimed to investigate the effect of Chronic Kidney Diseases (CKD) and Metabolic Syndrome (MetS) on the incidence of Coronary Heart Disease (CHD).

Methods: In order to record time to CHD events, a sample of 6,507 individuals (mean age 47.4 years, 43.4% males) was followed for nearly 10 years. Participants were also categorized into four groups according to presence/absence of CKD and MetS. Then, using a Multivariate Cox Regression, the Hazard Ratio (HR) of each group was estimated relative to individuals free of both CKD and MetS separately for obese (BMI&ge27.1 Kg/m2) and non-obese persons (BMI<27.1 Kg/m2).

Results: HR for non-obese patients with CKD but not MetS was obtained 2.06 (95%CI: 1.28-3.31) in men and 2.56 (1.04-6.31) in women. However, these associations were not significant for obese patients. Furthermore, among non-obese men and women with MetS alone, HR was estimated 2.52 (1.71-3.73) and 4.68 (2.20-9.95), respectively. For obese patients, these values were 1.70 (1.05-2.78) and 1.90 (1.16-3.13), respectively.

Conclusion: The results reflect that among those who had MetS alone, the risk of CHD incidence was twice higher in non-obese individuals compared to obese patients.

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Type of Study: Research | Subject: General
Received: 2015/08/16 | Accepted: 2015/08/16 | Published: 2015/08/16

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