Volume 11, Number 4 (Vol 11, No.4, Winter 2016 2016)                   irje 2016, 11(4): 55-62 | Back to browse issues page


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Masoudi S, Pourdanesh F, Biglarian A, Rahgozar M. Evaluating follow up time and Prognosis in Patients Diagnosed with Oral Squamous Cell Carcinoma, using the Multistate MarKov Model. irje. 2016; 11 (4) :55-62
URL: http://irje.tums.ac.ir/article-1-5463-en.html

1- Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Evin, Daneshjou Blvd, Koodakyar Ave, Tehran, Iran Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Evin, Daneshjou Blvd, Koodakyar Ave, Tehran, Iran
2- Associate Professor Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Evin, Daneshjou Blvd, Koodakyar Ave. Tehran, Iran Associate Professor Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Evin, Daneshjou Blvd, Koodakyar Ave. Tehran, Iran
3- Assistant Professor of Biostatistics, Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Evin, Daneshjou Blvd, Koodakyar Ave. Tehran, Iran Assistant Professor of Biostatistics, Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Evin, Daneshjou Blvd, Koodakyar Ave. Tehran, Iran
4- Associate Professor of Biostatistics, Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Evin, Daneshjou Blvd, Koodakyar Ave. Tehran, Iran Associate Professor of Biostatistics, Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Evin, Daneshjou Blvd, Koodakyar Ave. Tehran, Iran , m_rahgozar2003@yahoo.com.au
Abstract:   (3639 Views)

Background and Objectives: The aim of this study was to analyze the risks of local recurrence, second primary tumor, and metastasis in oral squamous cell carcinoma (OSCC) patients and to present their prognosis after treatment.

Methods: In this retrospective cohort study, 147 patients with oral squamous cell carcinoma (OSCC) who were older than 40 years were included using the data of 1973–2010 Surveillance, Epidemiology, and End Results (SEER) Program in the United States. The variables included gender, race, stage, histologic grade, tumor site, treatment modalities, and dates of diagnosis and death. Markov Multistate model was used for analysis.

Results: At a median follow-up of 33 months, local recurrence, second primary tumor, and distant metastasis rates were 34.01%, 85.03%, and 17.01% respectively and 40.13% of the patients died. Patients with cervical lymph nodes were at risk of second primary tumor 1.37 (1.05-2.05) times higher than early stage patients and were 2.33 (1.29-4.18) times more likely to die. After one year, the risk of death for patients with local recurrence or second primary tumor was almost similar but after 5 years, the risk of death was higher for local recurrence than second primary tumor.

Conclusion: Awareness of the next state and its time with respect to the patient’s clinical status can be one of the appropriate methods for timely diagnosis and treatment to reduce the mortality rate of OSCC patients.

Full-Text [PDF 1577 kb]   (797 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/04/24 | Accepted: 2016/04/24 | Published: 2016/04/24

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