Volume 16, Issue 1 (Vol.16, No.1 2020)                   irje 2020, 16(1): 20-29 | Back to browse issues page

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Moatamedizadeh B, Ansari H, Payandeh A, Tabatabae S, Ramazanpouramirdehi A. Evaluation of Tuberculosis Recurrence and Its Determinants in the Southeast of Iran: A Nested Case-Control Study Based on Data From 2012 to 2018. irje. 2020; 16 (1) :20-29
URL: http://irje.tums.ac.ir/article-1-6516-en.html
1- Ms in Epidemiology, Department of Epidemiology and Biostatistics, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
2- Associate professor of Epidemiology, Department of Epidemiology and Biostatistics, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran , ansarih@razi.tums.ac.ir
3- Assistant Professor of Biostatistics, Department of Epidemiology and Biostatistics, Community Nursing Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
4- Associate professor of Epidemiology, Department of Epidemiology and Biostatistics, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
Abstract:   (307 Views)
Background and Objectives: In addition to effective treatment, tuberculosis recurrence is a very important challenge regarding the treatment of this infection. This study was conducted to evaluate the risk factors associated with tuberculosis recurrence.
 
Methods: In this nested case-control study, 202 tuberculosis patients with recurrence and 202 matched controls in terms of age, sex and place of residence were studied. The cases and controls were selected from a cohort of tuberculosis patients in Sistan and Baluchestan province between 2011 and 2018. The data were collected using interviews and patients’ records. The independent t-test, chi-square and multiple conditional logistic regression were used to analyze the data.
 
Results: The drug abuse history (OR=6.1), 3+ smear positive (OR=3.03), chest X-ray suggestive of tuberculosis (OR=4.9), drug resistance (OR=7.3), low socioeconomic status (OR=3.9), weight loss (OR=3.1), chest pain (OR=3.2), history of digestive disease (OR=22.1), smoking (OR=6.1), and imprisonment (OR=3.7) significantly increased the chance of recurrence among tuberculosis patients (p<0.05). On the other hand, the chance of recurrence was significantly lower in patients with coughs (OR=0.29) and a small family size (OR=0.28).
 
Conclusion: According to the results, tobacco use, drug use, low socio-economic status, life conditions, and disease conditions are the most important determinants of tuberculosis recurrence. In general, epidemiologic factors related to tuberculosis recurrence are not similar in different regions; therefore, educational programs for patients and their families and prevention methods should be considered based on related factors in different regions.
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Type of Study: Research | Subject: Epidemiology
Received: 2020/06/23 | Accepted: 2020/06/23 | Published: 2020/06/23

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